1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).
2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.
3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.
Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:
1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).
2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.
3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.
Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:
Cialis can cause a serious drop in blood pressure, which can amplify the risk of experiencing these side effects. Taking this medication with grapefruit and grapefruit juice can enhance tadalafil's blood pressure-lowering effects. Avoid consuming grapefruit or grapefruit juice while taking this medication.
Both Cialis and alpha-blockers can cause a side effect of erectile dysfunction (ED), but theophenchogenic effects of Cialis and alpha-blockers can be more potent than those of nitrates and nitric oxide donors. Taking Cialis and alpha-blockers together can enhance the blood pressure-lowering effects of the medication. If you take Cialis and alpha-blockers together, you may experience dizziness or fainting, and aplastic anaemia mayennis (a serious skin reaction) can occur.
D.
Erection problems (impotence) are very common, particularly in men over 40.
Most men occasionally fail to get or keep an erection. This is usually due to stress, tiredness, anxiety or drinking too much alcohol, and it’s nothing to worry about.
If it happens more often, it may be caused by physical or emotional problems.
Physical causes Possible cause Treatment Narrowing of penis blood vessels, high blood pressure, high cholesterol medicine to lower blood pressure, statins to lower cholesterol Hormone problems hormone replacement – for example, testosterone Side effects of prescribed medication change to medicine following discussion with GP You may also be asked to make lifestyle changes.
Do lose weight if you’re overweight stop smoking eat a healthy diet exercise daily try to reduce stress and anxiety
Don’t cycle for a while (if you cycle more than 3 hours a week) drink more than 14 units of alcohol a week
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. These effects are normally mild to moderate in nature.
If you experience any of the following side effects stop using the medicine and seek medical help immediately:
allergic reactions including rashes (frequency uncommon). chest pain – do not use nitrates but seek immediate medical assistance (frequency uncommon). priapism, a prolonged and possibly painful erection after taking CIALIS (frequency rare). If you have such an erection, which lasts continuously for more than 4 hours you should contact a doctor immediately. sudden loss of vision (frequency rare). Other side effects have been reported:
Common (seen in 1 to 10 in every 100 patients)
headache, back pain, muscle aches, pain in arms and legs, facial flushing, nasal congestion, and indigestion. Uncommon (seen in 1 to 10 in every 1,000 patients)
dizziness, stomach ache, feeling sick, being sick (vomiting), reflux, blurred vision, eye pain, difficulty in breathing, presence of blood in urine, prolonged erection, pounding heartbeat sensation, a fast heart rate, high blood pressure, low blood pressure, nose bleeds, ringing in the ears, swelling of the hands, feet or ankles and feeling tired. Rare (seen in 1 to 10 in every 10,000 patients)
fainting, seizures and passing memory loss, swelling of the eyelids, red eyes, sudden decrease or loss of hearing, hives (itchy red welts on the surface of the skin), penile bleeding, presence of blood in semen and increased sweating. Heart attack and stroke have also been reported rarely in men taking CIALIS. Most of these men had known heart problems before taking this medicine.
Partial, temporary, or permanent decrease or loss of vision in one or both eyes has been rarely reported.
Eli Lilly has announced that its US patent for Viagra, which is used to treat erectile dysfunction, has ended, making it the first pharmaceutical company to do so.
Lilly said the patent has been approved and will expire in April 2024.
“Today’s approval marks the first time a drug to reach the market has to compete with Viagra in a single product,” said Les Funtleyder, Lilly’s senior vice president of global pharmaceuticals.
Eli Lilly was first to receive FDA approval in the US in 2003, when Viagra was first approved in the United States.
Viagra is a phosphodiesterase type 5 inhibitor, which relaxes the smooth muscle of the penis and increases blood flow. It is the first drug to treat erectile dysfunction.
Viagra works by increasing blood flow to the penis, enabling an erection to occur.
“We applaud Lilly for the decision,” said Dr. Steven Nissen, chief medical officer of the company. “We believe that Viagra is a significant breakthrough for men and we are excited about the potential for this to continue to advance, and we are very mindful of the impact that this has on the market.”
Lilly said it is committed to improving the drug’s market and is evaluating the latest regulatory developments and discussions with regulatory authorities in the US and Europe.
“Today’s approval marks the first time a drug to reach the market has to compete with Viagra in a single product,” said Les Funtleyder, senior vice president of the company. “We are very mindful of the impact that this has on the market. We are pleased to see Viagra remain available as an option for patients with erectile dysfunction.”
Lilly said that the US patent for Viagra will expire in April 2024 and that it will be able to sell its generic version of the drug in the US in April 2024.
“We remain committed to improving the drug’s market and are evaluating the latest regulatory developments,” said Les Funtleyder.
Lilly’s patent on Viagra expired in 2012. In 2014, Pfizer Inc., the manufacturer of Viagra, applied to the US Food and Drug Administration for approval to sell its generic version of the drug, Lilly’s Cialis.
However, Lilly withdrew its application from the US FDA in June 2014.
Cialis, marketed by Eli Lilly and Company, was the first pharmaceutical company to issue its generic, Cialis.
Stade de France Pharmacy